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LspA-independent action of globomycin on Mycobacterium tuberculosis JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY Banaiee, N., Jacobs, W. R., Ernst, J. D. 2007; 60 (2): 414-416

Abstract

The objective of this study was to investigate the antimicrobial activity and specificity of globomycin, an inhibitor of lipoprotein signal peptidase II (LspA), against Mycobacterium tuberculosis.The mycobactericidal and mycobacteriostatic activity of globomycin was determined by optical density and cfu plating. The specificity of globomycin was determined by western immunoblotting using anti-MPT83 antibody.Globomycin is mycobactericidal at concentrations>or=40 mg/L. However, at 80 mg/L, the processing of the lipoprotein MPT-83 is unaffected and growth-inhibitory effect of globomycin is unchanged in an lspA null mutant (DeltalspA::lspAmut) lacking the putative drug target.Globomycin kills M. tuberculosis through a mechanism that is independent of LspA.

View details for DOI 10.1093/jac/dkm223

View details for Web of Science ID 000248986500031

View details for PubMedID 17579235