Genomewide clonal. analysis of lethal mutations in the Drosophila melanogaster eye: Comparison of the X chromosome and autosomes GENETICS Call, G. B., Olson, J. M., Chen, J., Villarasa, N., Ngo, K. T., Yabroff, A. M., Cokus, S., Pellegrini, M., Bibikova, E., Bui, C., Cespedes, A., Chan, C., Chan, S., Cheema, A. K., Chhabra, A., Chitsazzadeh, V., Do, M., Fang, Q. A., Folick, A., Goodstein, G. L., Huang, C. R., Hung, T., Kim, E., Kim, W., Kim, Y., Kohan, E., Kuoy, E., Kwak, R., Lee, E., Lee, J., Lin, H., Liu, H. A., Moroz, T., Prasad, T., Prashad, S. L., Patananan, A. N., Rangel, A., Rosselli, D., Sidhu, S., Sitz, D., Taber, C. E., Tan, J., Topp, K., Tran, P., Tran, Q., Unkovic, M., Wells, M., Wickland, J., Yackle, K., Yavari, A., Zaretsky, J. M., Allen, C. M., Alli, L., An, J., Anwar, A., Arevalo, S., Ayoub, D., Badal, S. S., Baghdanian, A., Baghdanian, A. H., Baumann, S. A., Becerra, V. N., Chan, H. J., Chang, A. E., Cheng, X. A., Chin, M., Chong, F., Crisostomo, C., Datta, S., Delosreyes, A., Diep, F., Ekanayake, P., Engeln, M., Evers, E., Farshidi, F., Fischer, K., Formanes, A. J., Gong, J., Gupta, R., Haas, B. E., Hahm, V., Hsieh, M., Hui, J. Z., Iao, M. L., Jin, S. D., Kim, A. Y., Kim, L. S., King, M., Knudsen-Robbins, C., Kohanchi, D., Kovshilovskaya, B., Ku, A., Kung, R. W., Landig, M. E., Latterman, S. S., Lauw, S. S., Lee, D. S., Lee, J. S., Lei, K. C., Leung, L. L., Lerner, R., Lin, J., Lin, K., Lim, B. C., Lui, C. P., Liu, T. Q., Luong, V., Makshanoff, J., Mei, A., Meza, M., Mikhaeil, Y. A., Moarefi, M., Nguyen, L. H., Pai, S. S., Pandya, M., Patel, A. R., Picard, P. D., Safaee, M. M., Salame, C., Sanchez, C., Sanchez, N., Seifert, C. C., Shah, A., Shilgevorkyan, O. H., Singh, I., Soma, V., Song, J. J., Srivastava, N., Ana, J. L., Sun, C., Tan, D., Teruya, A. S., Tikia, R., Tran, T., Travis, E. G., Trinh, J. D., Vo, D., Walsh, T., Wong, R. S., Wu, K., Wu, Y., Yang, N. X., Yeranosian, M., Yu, J. S., Zhou, J. J., Zhu, R. X., Abrams, A., Abramson, A., Amado, L., Anderson, J., Bashour, K., Beyer, E., Bookatz, A., Brewer, S., Buu, N., Calvillo, S., Cao, J., Chan, A., Chan, J., Chang, A., Chang, D., Chang, Y., Chen, Y., Choi, J., Chou, J., Dang, P., Datta, S., Davarifar, A., Deravanesian, A., Desai, P., Fabrikant, J., Farnad, S., Fu, K., Garcia, E., Garrone, N., Gasparyan, S., Gayda, P., Go, S., Goffstein, C., Gonzalez, C., Guirguis, M., Hassid, R., Hermogeno, B., Hong, J., Hong, A., Hovestreydt, L., Hu, C., Huff, D., Jamshidian, F., Jen, J., Kahen, K., Kao, L., Kelley, M., Kho, T., Kim, Y., Kim, S., Kirkpatrick, B., Langenbacher, A., Laxamana, S., Lee, J., Lee, C., Lee, S., Lee, T. S., Lee, T., Lewis, G., Lezcano, S., Lin, P., Luu, T., Luu, J., Marrs, W., Marsh, E., Marshall, J., Min, S., Minasian, T., Minye, H., Misra, A., Morimoto, M., Moshfegh, Y., Murray, J., Nguyen, K., Nguyen, C., Nodado, E., O'Donahue, A., Onugha, N., Orjiakor, N., Padhiar, B., Paul, E., Pavel-Dinu, M., Pavlenko, A., Paz, E., Phaklides, S., Pham, L., Poulose, P., Powell, R., Pusic, A., Ramola, D., Regalia, K., Ribbens, M., Rifai, B., Saakyan, M., Saarikoski, P., Segura, M., Shadpour, F., Shemmassian, A., Singh, R., Singh, V., Skinner, E., Solomin, D., Soneji, K., Spivey, K., Stageberg, E., Stavchanskiy, M., Tekchandani, L., Thai, L., Thiyanaratnam, J., Tong, M., Toor, A., Tovar, S., Trangsrud, K., Tsang, W., Uemura, M., Vollmer, E., Weiss, E., Wood, D., Wu, J., Wu, S., Wu, W., Xu, Q., Yamauchi, Y., Yarosh, W., Yee, L., Yen, G., Banerjee, U. 2007; 177 (2): 689-697

Abstract

Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development as that found on the autosomes.

View details for DOI 10.1534/genetics.107.077735

View details for Web of Science ID 000250657800003

View details for PubMedID 17720911