Noninvasive molecular neuroimaging using reporter genes: Part I, principles revisited AMERICAN JOURNAL OF NEURORADIOLOGY Massoud, T. F., Singh, A., Gambhir, S. S. 2008; 29 (2): 229-234

Abstract

In this first article, we review the basic principles of using reporter genes for molecular imaging of the brain in living subjects. This approach is emerging as a valuable tool for monitoring gene expression in diverse applications in laboratory animals, including the study of gene-targeted and trafficking cells, gene therapies, transgenic animals, and more complex molecular interactions within the central nervous system. Further development of more sensitive and selective reporters, combined with improvements in detection technology, will consolidate the position of in vivo reporter gene imaging as a versatile method for greater understanding of intracellular biologic processes and underlying molecular neuropathology and will potentially establish a future role in the clinical management of patients with neurologic diseases.

View details for DOI 10.3174/ajnr.A0864

View details for Web of Science ID 000253345200011

View details for PubMedID 18024575