Temporal Relationship Between Antitumor Necrosis Factor-alpha Antibody Therapy and Recrudescence of Head and Neck Squamous Cell Carcinoma LARYNGOSCOPE Engel, S. H., Hullar, T. E., Adkins, D. R., Thorstad, W. L., Sunwoo, J. B. 2008; 118 (3): 450-452


Tumor necrosis factor (TNF)-alpha inhibitors have been used effectively to treat rheumatoid arthritis and inflammatory bowel disease. Although the role of TNF-alpha in tumor development is not well understood, an increased risk of malignancies with anti-TNF-alpha therapy has been suggested. We report an instructive case of a patient, treated for Crohn's disease with infliximab, who presented with a neck abscess diagnosed to be head and neck squamous cell carcinoma. The patient's clinical course illustrates a temporal relationship between reappearance of his cancer after a complete response to therapy and the resumption of infliximab for worsening Crohn's disease.

View details for DOI 10.1097/MLG.0b013e31815abf4c

View details for Web of Science ID 000260661800012

View details for PubMedID 18090867