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ALZHEIMERS-DISEASE - BETA-AMYLOID PRECURSOR PROTEIN MESSENGER-RNA EXPRESSION IN MONONUCLEAR BLOOD-CELLS NEUROSCIENCE LETTERS Allen, J. S., Murphy, G. M., Eng, L. F., STULTZ, K. E., Davies, H. D., Pickford, L. B., Tinklenberg, J. R. 1991; 132 (1): 109-112

Abstract

beta-Amyloid precursor protein (beta APP) mRNA was examined in peripheral mononuclear blood cells (PMBCs) in Alzheimer's disease, Down's syndrome and control subjects. Total RNA from PMBCs was reverse transcribed and then amplified using the polymerase chain reaction (PCR). The 3 major beta APP transcripts were expressed in PMBCs from all subjects. These results suggest that PMBCs could be a circulating source for abnormal amyloid deposition in the brain and in peripheral tissues.

View details for Web of Science ID A1991GN66500029

View details for PubMedID 1838578