Mice without telomerase: what can they teach us about human cancer? NATURE MEDICINE Artandi, S. E., DePinho, R. A. 2000; 6 (8): 852-855

Abstract

Unicellular organisms, human cells and mice have provided insights into the processes of senescence, crisis, genomic instability and cancer in humans. Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to telomere dysfunction, and the suppression or promotion of cancer.

View details for Web of Science ID 000165473800015

View details for PubMedID 10932211