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EFFECT OF CYCLIZINE HYDROCHLORIDE ON LOWER ESOPHAGEAL SPHINCTER PRESSURE IN MAN SOUTH AFRICAN MEDICAL JOURNAL BROCKUTNE, J. G., Downing, J. W., DIMOPOULOS, G. E., MOSHAL, M. G. 1977; 51 (26): 977-978

Abstract

Gastro-oesophageal reflux and pulmonary aspiration of acid gastric content remain significant causes of morbidity and mortality. A drug which increases lower oesophageal sphincter (LOS) tone would reduce this hazard. The effect of LOS function of intravenous cyclizine (25 mg), in half the recommended adult dose, was investigated in 8 volunteers. Cyclizine increased the LOS pressure by an average of 14,4 cm H2O (P less than 0,005). Cyclizine, like metoclopramide, has a desirable functional effect on the LOS. Both drugs are, in addition, potent anti-emetics. On the grounds of these pharmacological properties they are recommended in the preparation of patients for emergency surgery.

View details for Web of Science ID A1977DK95600019

View details for PubMedID 18802