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Proteomic insight into the pathogenesis of CAPN5-vitreoretinopathy. Scientific reports Velez, G. n., Yang, J. n., Li, A. S., Tsang, S. H., Bassuk, A. G., Mahajan, V. B. 2019; 9 (1): 7608

Abstract

CAPN5 Neovascular Inflammatory Vitreoretinopathy (CAPN5-NIV; OMIM 193235) is a poorly-understood rare, progressive inflammatory intraocular disease with limited therapeutic options. To profile disease effector proteins in CAPN5-NIV patient vitreous, liquid vitreous biopsies were collected from two groups: eyes from control subjects (n?=?4) with idiopathic macular holes (IMH) and eyes from test subjects (n?=?12) with different stages of CAPN5-NIV. Samples were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Protein expression changes were evaluated by principal component analysis, 1-way ANOVA (significant p-value?

View details for DOI 10.1038/s41598-019-44031-7

View details for PubMedID 31110225