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Catalysis of zinc transfer by D-penicillamine to secondary chelators JOURNAL OF MEDICINAL CHEMISTRY Chong, C. R., Auld, D. S. 2007; 50 (22): 5524–27

Abstract

The antiarthritis drug D-penicillamine (D-PEN) catalyzes zinc(II) transfer from carboxypeptidase A to chelators such as thionein and EDTA at a rate constant up to 400-fold faster than the uncatalyzed release. Once D-PEN releases zinc(II) from enzyme stronger chelators can tightly bind zinc(II) leading to complete and essentially irreversible inhibition. D-PEN is the first drug to inhibit a zinc protease by catalyzing metal removal, and the name "catalytic chelation" is proposed for this mechanism.

View details for DOI 10.1021/jm070803y

View details for Web of Science ID 000250557100031

View details for PubMedID 17918925