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Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Byrne, S. T., Gu, P., Zhou, H., Denkin, S. M., Chong, C., Sullivan, D., Liu, J. O., Zhang, Y. 2007; 51 (12): 4495–97

Abstract

Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 microg/ml and 0.13 microg/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titers of 1:2 and 1:4, respectively, in mice given 100 mg/kg orally.

View details for DOI 10.1128/AAC.00753-07

View details for Web of Science ID 000251472100046

View details for PubMedID 17876006

View details for PubMedCentralID PMC2168016