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Quantitative electrocorticographic biomarkers of clinical outcomes in mesial temporal lobe epileptic patients treated with the RNS system. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Arcot Desai, S., Tcheng, T. K., Morrell, M. J. 2019; 130 (8): 1364–74

Abstract

OBJECTIVES: Find interictal electrocorticographic (ECoG) biomarkers of clinical outcomes in mesiotemporal lobe (MTL) epilepsy patients.METHODS: In the NeuroPace RNS System clinical trials with 256 patients, 20 MTL patients with the most reduction in clinical seizures at Year 7 compared to baseline (upper response quartile; -96.5% median change) and 20 with the least reduction in clinical seizures (lower response quartile; -17.4% median change) were evaluated. Clinical and interictal ECoG features from the two response quartiles were compared.RESULTS: Demographic and clinical features were similar in the upper and lower response quartiles. Interictal spike rate (ISR) was substantially lower (p?25?Hz) were also different (p?

View details for DOI 10.1016/j.clinph.2019.05.017

View details for PubMedID 31212202