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Quantitative electrocorticographic biomarkers of clinical outcomes in mesial temporal lobe epileptic patients treated with the RNS system.

Quantitative electrocorticographic biomarkers of clinical outcomes in mesial temporal lobe epileptic patients treated with the RNS system. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Arcot Desai, S., Tcheng, T. K., Morrell, M. J. 2019; 130 (8): 1364–74

Abstract

OBJECTIVES: Find interictal electrocorticographic (ECoG) biomarkers of clinical outcomes in mesiotemporal lobe (MTL) epilepsy patients.METHODS: In the NeuroPace RNS System clinical trials with 256 patients, 20 MTL patients with the most reduction in clinical seizures at Year 7 compared to baseline (upper response quartile; -96.5% median change) and 20 with the least reduction in clinical seizures (lower response quartile; -17.4% median change) were evaluated. Clinical and interictal ECoG features from the two response quartiles were compared.RESULTS: Demographic and clinical features were similar in the upper and lower response quartiles. Interictal spike rate (ISR) was substantially lower (p?25?Hz) were also different (p?

View details for DOI 10.1016/j.clinph.2019.05.017

View details for PubMedID 31212202