A highly prevalent and genetically diversified Picornaviridae genus in South Asian children PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Kapoor, A., Victoria, J., Simmonds, P., Slikas, E., Chieochansin, T., Naeem, A., Shaukat, S., Sharif, S., Alam, M. M., Angez, M., Wang, C., Shafer, R. W., Zaidi, S., Delwart, E. 2008; 105 (51): 20482-20487


Viral metagenomics focused on particle-protected nucleic acids was used on the stools of South Asian children with nonpolio acute flaccid paralysis (AFP). We identified sequences distantly related to Seneca Valley virus and cardioviruses that were then used as genetic footholds to characterize multiple viral species within a previously unreported genus of the Picornaviridae family. The picornaviruses were detected in the stools of >40% of AFP and healthy Pakistani children. A genetically diverse and highly prevalent enteric viral infection, characteristics similar to the Enterovirus genus, was therefore identified substantially expanding the genetic diversity of the RNA viral flora commonly found in children.

View details for DOI 10.1073/pnas.0807979105

View details for Web of Science ID 000261995600083

View details for PubMedID 19033469

View details for PubMedCentralID PMC2629322