Cortical Brain Age from Pre-treatment to Post-chemotherapy in Patients with Breast Cancer. Neurotoxicity research Henneghan, A., Rao, V., Harrison, R. A., Karuturi, M., Blayney, D. W., Palesh, O., Kesler, S. R. 2020

Abstract

Chemotherapy-related cognitive impairment and associated brain changes may reflect accelerated brain aging; however, empirical evidence for this theory is limited. The purpose of this study was to measure brain aging in newly diagnosed patients with breast cancer treated with chemotherapy (n?=?43) and compare its longitudinal change to that of controls (n?=?50). Brain age indices, derived from cortical measures, were compared between women with breast cancer and matched healthy controls across 3 timepoints (time 1: pre-surgery, time 2: 1 month following chemotherapy completion, and time 3: 1-year post-chemotherapy). The breast cancer group showed a significant decrease in cortical thickness across the 3 timepoints (p?

View details for DOI 10.1007/s12640-019-00158-z

View details for PubMedID 31900898