Abstract

BACKGROUND AND OBJECTIVES: We sought to define the incidence and impact of Textbook Outcome (TO) on disease-freesurvival [DFS] among patients undergoing resection of pancreatic neuroendocrine tumors (PNET).METHODS: Patients undergoing resection of a PNET between 2000 and 2016 were identified using a multi-institutional database. TO was defined as no postoperative severe complications (Clavien-Dindo grade=III), no 90-day mortality, no prolonged length-of-hospital stay (LOS) (ie, >75th percentile), no 90-day readmission after discharge, and R0 resection. The 5-year DFS was calculated and the association with TO was examined.RESULTS: Among 821 patients with a PNET, median tumor size was 2.1cm (IQR 1.4-14.6). Resection consisted of pancreatoduodenectomy (PD) (n=231, 28.1%), distal pancreatectomy (DP) (n=492, 59.9%), and enucleation (EN) (n=98, 11.9%). Overall TO rate was 49.3% (n=405). The incidence of TO varied by procedure type (PD: 32.5% vs DP: 56.7% vs EN: 52.0%; P<.001). After adjusting for all competing factors, achievement of a TO was independently associated with improved DFS (hazard ratio: 0.54, 95% CI, 0.35-0.81; P=.003).CONCLUSIONS: Only one in two patients undergoing resection of a PNET achieved a TO, which varied markedly based on procedure type. Achievement of a TO was associated with improved DFS.

View details for DOI 10.1002/jso.25900

View details for PubMedID 32185804