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Adding Insult on Injury: Immunogenic Role for Donor-derived Cell-free DNA?

Adding Insult on Injury: Immunogenic Role for Donor-derived Cell-free DNA? Transplantation Dholakia, S. n., De Vlaminck, I. n., Khush, K. K. 2020

Abstract

Donor derived cell-free DNA in the blood circulation is an early marker of injury in solid-organ transplantation. Here, we review recent evidence that indicates that donor derived cell-free DNA may itself be a trigger of inflammation, thereby adding insult on injury. Early un-resolving molecular allograft injury measured via changes in dd-cfDNA may be an early warning sign, and may therefore enable stratification of patients who are at risk of subsequent allograft injury. Considering dd-cfDNA as a continuous and clinically significant biomarker opens up the potential for new management strategies, therapeutics, and ways to quantify interventions by considering the immunological potential of dd-cfDNA.

View details for DOI 10.1097/TP.0000000000003240

View details for PubMedID 32217943