Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

Find the latest information on COVID-19, monkeypox, and the flu vaccine

Time course of drug-related treatment-emergent adverse side effects of brivaracetam. Epilepsy & behavior : E&B Meador, K. J., Laloyaux, C. n., Elmoufti, S. n., Gasalla, T. n., Fishman, J. n., Martin, M. S., Klein, P. n. 2020; 111: 107212

Abstract

Treatment-emergent adverse events (TEAEs) in clinical trials are typically reported for the full duration of the treatment period including titration and maintenance. Drug-related central nervous system (CNS) TEAEs are common with antiseizure medications (ASMs) and can affect drug tolerability. In this report, we test the hypothesis that drug-related CNS TEAEs have early onset and decrease with time. Unlike prior ASM clinical trials, a novel design was used for brivaracetam (BRV) without initial drug titration allowing assessment of habituation to TEAEs separate from dose titration.Data were pooled from three studies (N01252 [NCT00490035], N01253 [NCT00464269], N01358 [NCT01261325]) in adult patients (=16?years of age) with focal seizures receiving BRV adjunctive therapy. This post hoc analysis reports data on the prevalence and incidence of all drug-related CNS TEAEs and all TEAEs over time in patients who received BRV doses of 50-200?mg/day (without titration) vs. placebo during a 12-week treatment period.A total of 1262 patients received the following: placebo (n?=?459), BRV 50?mg/day (n?=?200), BRV 100?mg/day (n?=?353), and BRV 200?mg/day (n?=?250). Both the incidence (p?

View details for DOI 10.1016/j.yebeh.2020.107212

View details for PubMedID 32544700