Abstract

BACKGROUND: The regional impact of COVID-19 on solid organ transplantation in the United States (US) has not been fully evaluated.METHODS: A retrospective analysis of month-to-month trends on waitlist additions, waitlist deaths, and transplant surgeries between all United Network for Organ Sharing (UNOS) regions was performed. A linear regression model trained on historical data was used to estimate anticipated transplantation volume.RESULTS: All UNOS Regions reported a decrease in total waitlist additions and transplant surgeries. The largest decreases in total transplants were identified in Regions 1,2,6 and 9; with Regions 2, 7, 8 and 9 noting the largest decrease in waitlist additions. Six of the 11 regions noted increases in waitlist deaths, with UNOS Regions 9, 1, and 2, all located within the Northeast, noting the highest percent increase in waitlist deaths at 170%, 89%, and 54%, respectively. The largest reductions in SOT and waitlist deaths were seen in kidney and lung transplantation. Current transplantation volume is significantly lower than the low range of the 95% CI derived from the linear regression model (2182 vs 3110, p<0.05) CONCLUSIONS:: Significant decreases in total waitlist additions and transplant surgeries with increases in waitlist deaths were noted in the majority of US transplant domains. The impact was especially prevalent in areas with high burden of COVID-19 infection. National and regional strategies aimed at minimizing disruptions in transplantation are needed.

View details for DOI 10.1097/TP.0000000000003391

View details for PubMedID 32675741