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Human Immunodeficiency Virus Type 1 Isolates with the Reverse Transcriptase (RT) Mutation Q145M Retain Nucleoside and Nonnucleoside RT Inhibitor Susceptibility ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Varghese, V., Mitsuya, Y., Shahriar, R., Bachmann, M. H., Fessel, W. J., Kagan, R. M., Shafer, R. W. 2009; 53 (5): 2196-2198

Abstract

Q145M, a mutation in a conserved human immunodeficiency virus type 1 reverse transcriptase (RT) region, was reported to decrease susceptibility to multiple RT inhibitors. We report that Q145M and other Q145 mutations do not emerge with RT inhibitors nor decrease RT inhibitor susceptibility. Q145M should not, therefore, be considered an RT inhibitor resistance mutation.

View details for DOI 10.1128/AAC.01593-08

View details for Web of Science ID 000265528700072

View details for PubMedID 19223644

View details for PubMedCentralID PMC2681550