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Abstract
Young women with breast cancer are increasingly choosing bilateral mastectomy (BM), yet little is known about short-term and long-term physical and psychosocial well-being following surgery in this population.To evaluate the differential associations of surgery with quality of life (QOL) and psychosocial outcomes from 1 to 5 years following diagnosis.Cohort study.Multicenter, including academic and community hospitals in North America.Women age =40 when diagnosed with Stage 0-3 with unilateral breast cancer between 2006 and 2016 who had surgery and completed QOL and psychosocial assessments.Primary breast surgery including breast-conserving surgery (BCS), unilateral mastectomy (UM), and BM.Physical functioning, body image, sexual health, anxiety and depressive symptoms were assessed in follow-up.Of 826 women, mean age at diagnosis was 36.1 years; most women were White non-Hispanic (86.7%). Regarding surgery, 45% had BM, 31% BCS, and 24% UM. Of women who had BM/UM, 84% had reconstruction. While physical functioning, sexuality, and body image improved over time, sexuality and body image were consistently worse (higher adjusted mean scores) among women who had BM vs BCS (body image: year 1, 1.32 vs 0.64; P?
View details for DOI 10.1001/jamasurg.2020.3325
View details for PubMedID 32936216