Three-Dimensional Amide Proton Transfer MR Imaging of Gliomas: Initial Experience and Comparison With Gadolinium Enhancement JOURNAL OF MAGNETIC RESONANCE IMAGING Zhou, J., Zhu, H., Lim, M., Blair, L., Quinones-Hinojosa, A., Messina, S. A., Eberhart, C. G., Pomper, M. G., Laterra, J., Barker, P. B., van Zijl, P. M., Blakeley, J. O. 2013; 38 (5): 1119–28


To investigate the feasibility of a three-dimensional amide-proton-transfer (APT) imaging sequence with gradient- and spin-echo readouts at 3 Tesla in patients with high- or low-grade gliomas.Fourteen patients with newly diagnosed gliomas were recruited. After B0 inhomogeneity correction on a voxel-by-voxel basis, APT-weighted images were reconstructed using a magnetization-transfer-ratio asymmetry at offsets of ±3.5 ppm with respect to the water resonance. Analysis of variance post hoc tests were used for statistical evaluations, and results were validated with pathology.In six patients with gadolinium-enhancing high-grade gliomas, enhancing tumors on the postcontrast T1 -weighted images were consistently hyperintense on the APT-weighted images. Increased APT-weighted signal intensity was also clearly visible in two pathologically proven, high-grade gliomas without gadolinium enhancement. The average APT-weighted signal was significantly higher in the lesions than in the contralateral normal-appearing brain tissue (P < 0.001). In six low-grade gliomas, including two with gadolinium enhancement, APT-weighted imaging showed iso-intensity or mild punctate hyperintensity within all the lesions, which was significantly lower than that seen in the high-grade gliomas (P < 0.001).The proposed three-dimensional APT imaging sequence can be incorporated into standard brain MRI protocols for patients with malignant gliomas.

View details for DOI 10.1002/jmri.24067

View details for Web of Science ID 000326146900015

View details for PubMedID 23440878

View details for PubMedCentralID PMC3664658