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Challenges in Immunotherapy Presented by the Glioblastoma Multiforme Microenvironment

Challenges in Immunotherapy Presented by the Glioblastoma Multiforme Microenvironment CLINICAL & DEVELOPMENTAL IMMUNOLOGY Jackson, C., Ruzevick, J., Phallen, J., Belcaid, Z., Lim, M. 2011: 732413

Abstract

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. Despite intensive treatment, the prognosis for patients with GBM remains grim with a median survival of only 14.6 months. Immunotherapy has emerged as a promising approach for treating many cancers and affords the advantages of cellular-level specificity and the potential to generate durable immune surveillance. The complexity of the tumor microenvironment poses a significant challenge to the development of immunotherapy for GBM, as multiple signaling pathways, cytokines, and cell types are intricately coordinated to generate an immunosuppressive milieu. The development of new immunotherapy approaches frequently uncovers new mechanisms of tumor-mediated immunosuppression. In this review, we discuss many of the current approaches to immunotherapy and focus on the challenges presented by the tumor microenvironment.

View details for DOI 10.1155/2011/732413

View details for Web of Science ID 000298701200001

View details for PubMedID 22190972

View details for PubMedCentralID PMC3235820