A compendium answering 150 questions on COVID-19 and SARS-CoV-2

A compendium answering 150 questions on COVID-19 and SARS-CoV-2 ALLERGY Riggioni, C., Comberiati, P., Giovannini, M., Agache, I., Akdis, M., Alves-Correia, M., Anto, J. M., Arcolaci, A., Azkur, A., Azkur, D., Beken, B., Boccabella, C., Bousquet, J., Breiteneder, H., Carvalho, D., de las Vecillas, L., Diamant, Z., Eguiluz-Gracia, I., Eiwegger, T., Eyerich, S., Fokkens, W., Gao, Y., Hannachi, F., Johnston, S. L., Jutel, M., Karavelia, A., Klimek, L., Moya, B., Nadeau, K. C., O'Hehir, R., O'Mahony, L., Pfaar, O., Sanak, M., Schwarze, J., Sokolowska, M., Torres, M. J., van de Veen, W., van Zelm, M. C., Wang, D., Zhang, L., Jimenez-Saiz, R., Akdis, C. A. 2020; 75 (10): 2503–41

Abstract

In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.

View details for DOI 10.1111/all.14449

View details for Web of Science ID 000550399700001

View details for PubMedID 32535955

View details for PubMedCentralID PMC7323196