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Revisiting Stem Cell-Based Clinical Trials for Ischemic Stroke.
Revisiting Stem Cell-Based Clinical Trials for Ischemic Stroke. Frontiers in aging neuroscience He, J. Q., Sussman, E. S., Steinberg, G. K. 2020; 12: 575990Abstract
Stroke is the leading cause of serious long-term disability, significantly reducing mobility in almost half of the affected patients aged 65 years and older. There are currently no proven neurorestorative treatments for chronic stroke. To address the complex problem of restoring function in ischemic brain tissue, stem cell transplantation-based therapies have emerged as potential restorative therapies. Aligning with the major cell types found within the ischemic brain, stem-cell-based clinical trials for ischemic stroke have fallen under three broad cell lineages: hematopoietic, mesenchymal, and neural. In this review article, we will discuss the scientific rationale for transplanting cells from each of these lineages and provide an overview of published and ongoing trials using this framework.
View details for DOI 10.3389/fnagi.2020.575990
View details for PubMedID 33381020
View details for PubMedCentralID PMC7767918