Abstract

Neural prostheses are being developed to restore speech to people with neurological injury or disease. A key design consideration is where and how to access neural correlates of intended speech. Most prior work has examined cortical field potentials at a coarse resolution using electroencephalography (EEG) or medium resolution using electrocorticography (ECoG). The few studies of speech with single-neuron resolution recorded from ventral areas known to be part of the speech network. Here, we recorded from two 96- electrode arrays chronically implanted into the 'hand knob' area of motor cortex while a person with tetraplegia spoke. Despite being located in an area previously demonstrated to modulate during attempted arm movements, many electrodes' neuronal firing rates responded to speech production. In offline analyses, we could classify which of 9 phonemes (plus silence) was spoken with 81% single-trial accuracy using a combination of spike rate and local field potential (LFP) power. This suggests that high-fidelity speech prostheses may be possible using large-scale intracortical recordings in motor cortical areas involved in controlling speech articulators.

View details for Web of Science ID 000596231900022

View details for PubMedID 30440349