Universal definition and classification of heart failure: A report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure Endorsed by Canadian Heart Failure Society, Heart Failure Association of India, the Cardiac Society of Australia and New Zealand, and the Chinese Heart Failure Association. EUROPEAN JOURNAL OF HEART FAILURE Bozkurt, B., Coats, A. S., Tsutsui, H., Abdelhamid, M., Adamopoulos, S., Albert, N., Anker, S. D., Atherton, J., Bohm, M., Butler, J., Drazner, M. H., Felker, G., Filippatos, G., Fiuzat, M., Fonarow, G. C., Gomez-Mesa, J., Heidenreich, P., Imamura, T., Jankowska, E. A., Januzzi, J., Khazanie, P., Kinugawa, K., Lam, C. P., Matsue, Y., Metra, M., Ohtani, T., Piepoli, M., Ponikowski, P., Rosano, G. C., Sakata, Y., Seferovic, P., Starling, R. C., Teerlink, J. R., Vardeny, O., Yamamoto, K., Yancy, C., Zhang, J., Zieroth, S. 2021


In this document, we propose a universal definition of heart failure (HF) as a clinical syndrome with symptoms and/or signs caused by a structural and/or functional cardiac abnormality and corroborated by elevated natriuretic peptide levels and/or objective evidence of pulmonary or systemic congestion. We also propose revised stages of HF as: At-risk for HF (Stage A), Pre-heart failure (Stage B), Symptomatic HF (Stage C) and Advanced HF (Stage D). Finally, we propose a new and revised classification of HF according to left ventricular ejection fraction (LVEF). These include HF with reduced ejection fraction (HFrEF): symptomatic HF with LVEF =40%; HF with mildly reduced ejection fraction (HFmrEF): symptomatic HF with LVEF 41-49%; HF with preserved ejection fraction (HFpEF): symptomatic HF with LVEF =50%; and HF with improved ejection fraction (HFimpEF): symptomatic HF with a baseline LVEF =40%, a =10 point increase from baseline LVEF, and a second measurement of LVEF >?40%.

View details for DOI 10.1002/ejhf.2115

View details for Web of Science ID 000624807000001

View details for PubMedID 33605000