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H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?

H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far? Clinical and molecular allergy : CMA Borro, M., Negrini, S., Long, A., Chinthrajah, S., Murdaca, G. 2021; 19 (1): 4

Abstract

Histamine is a monoamine synthesized from the amino acid histidine that is well-known for its role in IgE-mediated anaphylaxis but has shown pleiotropic effects on the immune system, especially in order to promote inflammatory responses. H1-receptor antagonist are common drugs used in mild/moderate allergic reactions whereas H2-receptor antagonist are commonly administered in gastric ulcer but showed some properties in allergy too. The EAACI guidelines for diagnosis and treatment of anaphylactic reactions recommend their use as third-line therapy in adjunct to H1-antagonists. The purpose of this article is to produce a complete summary of findings and evidence known so far about the usefulness of H2-receptor antagonist in allergic reactons.

View details for DOI 10.1186/s12948-021-00143-y

View details for PubMedID 33849573