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Mammary Lobular Carcinoma-Like Salivary Gland Carcinoma: Report of a Rare Case. Head and neck pathology Lei, L., Van Staalduinen, E., Troxell, M., Ozawa, M. G., Zeineh, M., Berry, G. 2021

Abstract

Salivary and mammary glands are both exocrine organs sharing multiple tumorigenic processes. To the best of our knowledge, salivary gland tumors mimicking invasive lobular carcinoma of the breast have not yet been described. Herein, we report a case of a 62-year-old male who presented with progressive facial paralysis. Pathologic examination revealed an ill-defined epithelial neoplasm exhibiting discohesive growth set within an extensively fibrotic stroma. Both perineural and intraneural invasion were present. E-cadherin and p120 immunostaining showed aberrant cytoplasmic expression. Targeted next-generation sequencing detected a frameshift mutation of the CTNNA1 gene as the only known pathogenic variant. The patient was treated with surgical resection, immunotherapy, and chemotherapy. Currently, he is alive with disease twenty months after disease onset.

View details for DOI 10.1007/s12105-021-01344-2

View details for PubMedID 34115320