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Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel disease.

Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel disease. World journal of gastrointestinal oncology Weingarden, A. R., Rubin, S. J., Gubatan, J. 2021; 13 (8): 772-798

Abstract

Immune checkpoint inhibitors (ICI) have markedly changed the landscape of cancer therapy. By re-invigorating the immune system against tumors, ICI provide novel therapeutic options for a broad variety of malignancies, including many gastrointestinal (GI) cancers. However, these therapies can also induce autoimmune-like side effects in healthy tissue across the body. One of the most common of these side effects is ICI-mediated colitis and diarrhea (IMC). Here, we review the incidence and risk of IMC in ICI therapy, with a focus on what is known regarding IMC in patients with GI malignancies. We also discuss data available on the use of ICI and risk of IMC in patients with pre-existing inflammatory bowel disease, as these patients may have increased risk of IMC due to their underlying intestinal pathology.

View details for DOI 10.4251/wjgo.v13.i8.772

View details for PubMedID 34457186

View details for PubMedCentralID PMC8371513