New to MyHealth?
Manage Your Care From Anywhere.
Access your health information from any device with MyHealth. You can message your clinic, view lab results, schedule an appointment, and pay your bill.
ALREADY HAVE AN ACCESS CODE?
DON'T HAVE AN ACCESS CODE?
NEED MORE DETAILS?
MyHealth for Mobile
Activation of TRAIL-DR5 pathway promotes sensorineural degeneration in the inner ear
Activation of TRAIL-DR5 pathway promotes sensorineural degeneration in the inner ear AGING CELL Kao, S., Soares, V. R., Kristiansen, A. G., Stankovic, K. M. 2016; 15 (2): 301-308Abstract
Tumor necrosis factor (TNF) family cytokines are important mediators of inflammation. Elevated levels of serum TNF-a are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF-related apoptosis-inducing ligand (TRAIL) and its signaling death receptor 5 (DR5) in the murine inner ear and show that exogenous TRAIL can trigger hair cell and neuronal degeneration, which can be partly prevented with DR5-blocking antibodies.
View details for DOI 10.1111/acel.12437
View details for Web of Science ID 000372880500011
View details for PubMedID 26791792
View details for PubMedCentralID PMC4783338