Older Age as a Predictive Risk Factor for Acute Mountain Sickness. The American journal of medicine Small, E., Phillips, C., Marvel, J., Lipman, G. 2021

Abstract

BACKGROUND: Older populations are increasing and comprise a substantial portion of high-altitude travelers. Aging physiology may influence susceptibility to acute mountain sickness, though prior research remains inconclusive. The goal of this study was to investigate the relationship between increasing age and acute mountain sickness.MATERIALS & METHODS: This study was a pooled analysis of five prospective randomized controlled trials conducted at White Mountain, California from 2010, 2016-2019 with identical 4-hour rapid ascent from 1242 m to overnight sojourn at 3810 m. Acute mountain sickness was defined by the 2018 Lake Louise Questionnaire criteria.RESULTS: 491 participants were analyzed, 234 (48%) diagnosed with acute mountain sickness and 71 (14%) with moderate acute mountain sickness. Mean age was 37(±13). There was no significant correlation between Lake Louise Questionnaire severity and age (r?=?-0.02, 95% CI -0.11 to 0.07, p?=?0.7), 40 year-old dichotomy (t?=?-0.6, 95% CI -0.53 to 0.28, p?=?0.6), or decade of life (p?=?0.4). Logistic regression found no increased odds of acute mountain sickness for increasing age by decade of life (OR =1.0, 95% CI 0.97 to 1.0) or 40 year-old dichotomy (OR?=?1.4, 95% 0.97 to 2.1. A history of acute mountain sickness increased odds of acute mountain sickness (OR?=?3.2, 95% CI 1.5 to 7.7).CONCLUSIONS: Older age was not associated with incidence nor severity of acute mountain sickness. A history of altitude illness increased odds of acute mountain sickness and should be used for pre-ascent risk stratification.

View details for DOI 10.1016/j.amjmed.2021.10.003

View details for PubMedID 34715059