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Stanford Health Care

COVID-19 and Cardiovascular Disease

COVID-19 and Cardiovascular Disease CIRCULATION Clerkin, K. J., Fried, J. A., Raikhelkar, J., Sayer, G., Griffin, J. M., Masoumi, A., Jain, S. S., Burkhoff, D., Kumaraiah, D., Rabbani, L., Schwartz, A., Uriel, N. 2020; 141 (20): 1648-1655

Abstract

Coronavirus disease 2019 (COVID-19) is a global pandemic affecting 185 countries and >3?000?000 patients worldwide as of April 28, 2020. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2, which invades cells through the angiotensin-converting enzyme 2 receptor. Among patients with COVID-19, there is a high prevalence of cardiovascular disease, and >7% of patients experience myocardial injury from the infection (22% of critically ill patients). Although angiotensin-converting enzyme 2 serves as the portal for infection, the role of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers requires further investigation. COVID-19 poses a challenge for heart transplantation, affecting donor selection, immunosuppression, and posttransplant management. There are a number of promising therapies under active investigation to treat and prevent COVID-19.

View details for DOI 10.1161/CIRCULATIONAHA.120.046941

View details for Web of Science ID 000536791300012

View details for PubMedID 32200663