Impact of Viral Etiology on Postoperative De Novo Recurrence After Hepatectomy for Hepatocellular Carcinoma in Cirrhotic Patients JOURNAL OF GASTROINTESTINAL SURGERY Sasaki, K., Shindoh, J., Nishioka, Y., Margonis, G. A., Sugawara, T., Andreatos, N., Hashimoto, M., Pawlik, T. M. 2017; 21 (3): 487-495


Liver cirrhosis (LC) and hepatocellular carcinoma (HCC) are associated with viral hepatitis, especially hepatitis B virus (HBV) and hepatitis C virus (HCV). Whether differences exist in postoperative de novo carcinogenesis from established cirrhosis according to viral etiology remains unclear.Data from 313 LC patients with viral hepatitis (HBV-LC, n?=?108 and HCV-LC, n?=?205) who underwent curative-intent hepatectomy for HCC were retrospectively collected. Clinicopathological characteristics, cumulative recurrence, chronological change of recurrence rate, and predictors of recurrence were analyzed.Baseline patient characteristics were different among patients with HBV versus HCV as HCC-LC patients had a lower albumin, higher alanine transaminase, and higher incidence of tumor multicentricity (all P?

View details for DOI 10.1007/s11605-016-3344-3

View details for Web of Science ID 000395392100008

View details for PubMedID 28050767