[A case report of advanced gallbladder cancer with multiple liver metastases effectively treated by concentrated therapy with S-1]. Gan to kagaku ryoho. Cancer & chemotherapy Tomizawa, K., Sasaki, K., Matsuda, M., Hashimoto, M., Udagawa, H., Sawada, T., Watanabe, G. 2010; 37 (9): 1779-82

Abstract

A 65 -year-old male was admitted to our hospital because of epigastregia. Computed tomography (CT) and abdominal ultrasonography (AUS) revealed advanced gallbladder cancer and two S5 liver metastases. Selective gallbladder angiogram revealed his cystic vein was draining into the portal vein (P5), so cholecystectomy and S4a+S5-subsegmentectomy were performed. Pathological study of the resected specimens showed three liver metastases. After surgical resection lumbar metastasis was suspected, so radiotherapy and UFT at 300mg/day were started. Next, we started oral administration of S-1 alone (100mg/body) for 4 weeks followed by a 2-week rest period as one course. 100mg/day was changed to 80mg/body after 3 courses because of grade 2 neutropenia. A total of 31 courses of S-1 80mg/day were administered postoperatively for five years. The patient is alive and free of disease five years and ten months after the operation.

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