Confocal Microscopy in the Esophagus and Stomach CLINICAL ENDOSCOPY Templeton, A., Hwang, J. 2013; 46 (5): 445-449


Probe-based confocal microscopy (pCLE) is actively being investigated for applications in the esophagus and stomach. The use of pCLE allows real-time in vivo microscopy to evaluate the microarchitecture of the mucosal epithelium. pCLE appears to be particularly useful in identifying mucosal dysplasia and early malignancies that cannot be clearly distinguished using high-definition white light endoscopy, chromoendoscopy, or magnification endoscopy. In addition, the ability to detect dysplastic tissue in real-time may shift the current screening practice from random biopsy to targeted biopsy of esophageal and gastric cancers and their precursor lesions. We will review the use of pCLE for detection and surveillance of upper gastrointestinal early luminal malignancy.

View details for DOI 10.5946/ce.2013.46.5.445

View details for Web of Science ID 000409983500004

View details for PubMedID 24143300

View details for PubMedCentralID PMC3797923