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Hybrid Polydimethylsiloxane Bioscaffold-Intravascular Catheter for Cellular Therapies.

Hybrid Polydimethylsiloxane Bioscaffold-Intravascular Catheter for Cellular Therapies. ACS applied bio materials Hu, S., Primavera, R., Razavi, M., Avadhani, A., Wang, J., Thakor, A. S. 2020; 3 (10): 6626-6632

Abstract

Type-1 diabetes (T1D) is caused by immune-mediated destruction of insulin-producing beta-cells, resulting in insulin deficiency and hyperglycemia. Islet transplantation is a potential treatment for T1D, but clinical implementation is hampered by islet availability and poor islet survival post-transplantation. To overcome these issues, we developed an intravascular multiside hole catheter with an interior polydimethylsiloxane (PDMS) bioscaffold capable of housing a cellular cargo. We used computational fluid dynamics to determine an optimized catheter design, which we then fabricated. Using our hybrid PDMS bioscaffold-intravascular catheter, we demonstrated that this platform can successfully maintain in vitro islet function and viability.

View details for DOI 10.1021/acsabm.0c00725

View details for PubMedID 35019389