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Cardiac structure and function and quality of life associations in HFpEF: An analysis from TOPCAT-Americas.
Cardiac structure and function and quality of life associations in HFpEF: An analysis from TOPCAT-Americas. International journal of cardiology Ferreira, J. P., Shah, A. M., Claggett, B. L., Pitt, B., Lewis, E. F., Solomon, S. D., Zannad, F. 1800Abstract
BACKGROUND: Patients with heart failure with preserved ejection fraction (HFpEF) have poor health-related quality of life (HR-QoL). However, the relationship between HR-QoL measures and the alterations of cardiac structure and function that are present in patients with HFpEF remains unknown.AIMS: To study the associations between HR-QoL and echocardiographic parameters in HFpEF.METHODS: Regression modelling in patients from TOPCAT-Americas who had both HR-QoL questionnaires and a baseline echocardiogram.RESULTS: A total of 631 patients (36% of the TOPCAT-Americas population) had both echocardiographic and HR-QoL at baseline. KCCQ-23 Overall Summary Score (OSS; 0-100 points) was negatively (higher echocardiographic values-poorer/lower HR-QoL scores) associated with left ventricular end-diastolic diameter (LVEDD: beta=-3.56 [-7.00 to -0.13] points-per-1cm, P=0.042), interventricular septum thickness (beta=-1.31 [-2.19 to -0.42] points-per-1mm, P=0.004), posterior wall thickness (beta=-1.57 [-2.52 to -0.63] points-per-1mm, P=0.001 and left atrial width (beta=-3.27 [-6.39 to -0.15], P=0.040) points-per-1cm, and positively (higher echocardiographic values-better/higher HR-QoL scores) associated with left ventricular end-diastolic volume index (LVEDVi: beta=0.23 [0.09 to 0.37] points-per-1ml/m2, P=0.002) and left ventricular end-systolic volume index (LVESVi: beta=0.41 [0.18 to 0.63] points-per-1ml/m2, P<0.001). Body mass index (BMI: beta=-0.74 [-1.02 to -0.47] points-per-1Kg/m2, P<0.001), diabetes (beta=-6.01 [-10.05 to -1.97], P=0.004), and asthma (beta=-6.78 [-13.52 to -0.04], P=0.049) were negatively associated with OSS. A similar pattern of associations was observed for KCCQ-23 Clinical Summary Score, EQ5D-VAS and NYHA class.CONCLUSION: In patients with HFpEF, HR-QoL measures were associated with cardiac structure and function alterations. Extra-cardiac factors were also associated with HR-QoL, which may influence HR-QoL results when testing cardiovascular drugs.
View details for DOI 10.1016/j.ijcard.2022.01.053
View details for PubMedID 35101539