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Recipient and Donor Outcomes After Living-Donor Liver Transplant for Unresectable Colorectal Liver Metastases. JAMA surgery Hernandez-Alejandro, R., Ruffolo, L. I., Sasaki, K., Tomiyama, K., Orloff, M. S., Pineda-Solis, K., Nair, A., Errigo, J., Dokus, M. K., Cattral, M., McGilvray, I. D., Ghanekar, A., Gallinger, S., Selzner, N., Claasen, M. P., Burkes, R., Hashimoto, K., Fujiki, M., Quintini, C., Estfan, B. N., Kwon, C. H., Menon, K. V., Aucejo, F., Sapisochin, G. 2022

Abstract

Colorectal cancer is a leading cause of cancer-related death, and nearly 70% of patients with this cancer have unresectable colorectal cancer liver metastases (CRLMs). Compared with chemotherapy, liver transplant has been reported to improve survival in patients with CRLMs, but in North America, liver allograft shortages make the use of deceased-donor allografts for this indication problematic.To examine survival outcomes of living-donor liver transplant (LDLT) for unresectable, liver-confined CRLMs.This prospective cohort study included patients at 3 North American liver transplant centers with established LDLT programs, 2 in the US and 1 in Canada. Patients with liver-confined, unresectable CRLMs who had demonstrated sustained disease control on oncologic therapy met the inclusion criteria for LDLT. Patients included in this study underwent an LDLT between July 2017 and October 2020 and were followed up until May 1, 2021.Living-donor liver transplant.Perioperative morbidity and mortality of treated patients and donors, assessed by univariate statistics, and 1.5-year Kaplan-Meier estimates of recurrence-free and overall survival for transplant recipients.Of 91 evaluated patients, 10 (11%) underwent LDLT (6 [60%] male; median age, 45 years [range, 35-58 years]). Among the 10 living donors, 7 (70%) were male, and the median age was 40.5 years (range, 27-50 years). Kaplan-Meier estimates for recurrence-free and overall survival at 1.5 years after LDLT were 62% and 100%, respectively. Perioperative morbidity for both donors and recipients was consistent with established standards (Clavien-Dindo complications among recipients: 3 [10%] had none, 3 [30%] had grade II, and 4 [40%] had grade III; donors: 5 [50%] had none, 4 [40%] had grade I, and 1 had grade III).This study's findings of recurrence-free and overall survival rates suggest that select patients with unresectable, liver-confined CRLMs may benefit from total hepatectomy and LDLT.

View details for DOI 10.1001/jamasurg.2022.0300

View details for PubMedID 35353121