Radiomics analysis of amide proton transfer-weighted and structural MR images for treatment response assessment in malignant gliomas. NMR in biomedicine Jiang, S., Guo, P., Heo, H. Y., Zhang, Y., Wu, J., Jin, Y., Laterra, J., Eberhart, C. G., Lim, M., Blakeley, J. O. 2022: e4824


The purpose of this study was to evaluate the value of amide proton transfer-weighted (APTw) MRI radiomic features for the differentiation of tumor recurrence from treatment effect in malignant gliomas. Eighty-six patients who had suspected tumor recurrence after completion of chemoradiation or radiotherapy, and who had APTw-MRI data acquired at 3T, were retrospectively analyzed. Using a fluid-attenuated inversion recovery (FLAIR) image-based mask, radiomics analysis was applied to the processed APTw and structural MR images. A Chi-square automatic interaction detector (CHAID) decision tree was used for classification analysis. Models with and without APTw features were built using the same strategy. Ten-fold cross-validation was applied to obtain the overall classification performance of each model. Sixty patients were confirmed having as tumor recurrence, and the remaining were confirmed having as treatment effect, at median time points of 190 and 171 days post-therapy, respectively. There were 525 radiomic features extracted from each of the processed APTw and structural MR images. Based on these, the APTw-based model yielded the highest accuracy (86.0%) for the differentiation of tumor recurrence from treatment effect, compared with 74.4%, 76.7%, 83.7%, and 76.7% for T1 w, T2 w, FLAIR, and Gd-T1 w, respectively. Model classification accuracy was 82.6% when using the combined structural MR images (T1 w, T2 w, FLAIR, Gd-T1 w), and increased to 89.5% when using these structural plus APTw images. The corresponding sensitivity and specificity were 85.0% and 76.9% for the combination of structural MR images, and 85.0% and 100% after adding APTw image features. Adding APTw-based radiomic features increased MRI accuracy in the assessment of the treatment response in post-treatment malignant gliomas.

View details for DOI 10.1002/nbm.4824

View details for PubMedID 36057449