New to MyHealth?
Manage Your Care From Anywhere.
Access your health information from any device with MyHealth. You can message your clinic, view lab results, schedule an appointment, and pay your bill.
ALREADY HAVE AN ACCESS CODE?
DON'T HAVE AN ACCESS CODE?
NEED MORE DETAILS?
MyHealth for Mobile
Improving representativeness in trials: a call to action from the Global Cardiovascular Clinical Trialists Forum.
Improving representativeness in trials: a call to action from the Global Cardiovascular Clinical Trialists Forum. European heart journal Filbey, L., Zhu, J. W., D'Angelo, F., Thabane, L., Khan, M. S., Lewis, E., Patel, M. R., Powell-Wiley, T., Miranda, J. J., Zuhlke, L., Butler, J., Zannad, F., Van Spall, H. G. 2023Abstract
Participants enrolled in cardiovascular disease (CVD) randomized controlled trials are not often representative of the population living with the disease. Older adults, children, women, Black, Indigenous and People of Color, and people living in low- and middle-income countries are typically under-enrolled in trials relative to disease distribution. Treatment effect estimates of CVD therapies have been largely derived from trial evidence generated in White men without complex comorbidities, limiting the generalizability of evidence. This review highlights barriers and facilitators of trial enrollment, temporal trends, and the rationale for representativeness. It proposes strategies to increase representativeness in CVD trials, including trial designs that minimize the research burden on participants, inclusive recruitment practices and eligibility criteria, diversification of clinical trial leadership, and research capacity-building in under-represented regions. Implementation of such strategies could generate better and more generalizable evidence to reduce knowledge gaps and position the cardiovascular trial enterprise as a vehicle to counter existing healthcare inequalities.
View details for DOI 10.1093/eurheartj/ehac810
View details for PubMedID 36702610