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Impact of Periprocedural AdverseEventsAfter PCI and CABGon5-Year Mortality: The EXCEL Trial.

Impact of Periprocedural AdverseEventsAfter PCI and CABGon5-Year Mortality: The EXCEL Trial. JACC. Cardiovascular interventions Jain, S. S., Li, D., Dressler, O., Kotinkaduwa, L., Serruys, P. W., Kappetein, A. P., Sabik, J. F., Morice, M., Puskas, J., Kandzari, D. E., Karmpaliotis, D., Lembo, N. J., Brown, W. M., Banning, A. P., Stone, G. W. 2023; 16 (3): 303-313

Abstract

BACKGROUND: The relative risks for different periprocedural major adverse events (MAE) after percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) on subsequent mortality have not been described.OBJECTIVES: The aim of this study was to assess the association between periprocedural MAE occurring within 30days postprocedure and early and late mortality after left main coronary artery revascularization by PCI and CABG.METHODS: In the EXCEL (Evaluation of XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) trial, patients with left main disease were randomized to PCI vs CABG. The associations between 12 prespecified nonfatal MAE and subsequent 5-year all-cause and cardiovascular death in 1,858 patients were examined using logistic regression.RESULTS: One or more nonfatal MAE occurred in 111 of 935 patients (11.9%) after PCI and 419 of 923 patients (45.4%) after CABG (P< 0.0001). Patients with MAE were older and had more baseline comorbidities. Within 5 years, all-cause death occurred in 117 and 87 patients after PCI and CABG, respectively. Experiencing an MAE was a strong independent predictor of 5-year mortality after both PCI (adjusted OR: 4.61; 95%CI: 2.71-7.82) and CABG (adjusted OR: 3.25; 95%CI: 1.95-5.41). These associations were present within the first 30days and between 30days and 5 years postprocedure. Major or minor bleeding with blood transfusion=2 U was an independent predictor of 5-year mortality after both procedures. Stroke, unplanned revascularization for ischemia, and renal failure were significantly associated with mortality only after CABG.CONCLUSIONS: In the EXCEL trial, nonfatal periprocedural MAE were strongly associated with early and late mortality after both PCI and CABG for left main disease.

View details for DOI 10.1016/j.jcin.2022.10.011

View details for PubMedID 36792254