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The Treatment of Primary IgA Nephropathy: Change, Change, Change.
The Treatment of Primary IgA Nephropathy: Change, Change, Change. American journal of kidney diseases : the official journal of the National Kidney Foundation Caster, D. J., Lafayette, R. A. 2023Abstract
IgA nephropathy (IgAN) is the most common glomerular disease in the world. However, the approach to treatment remains controversial. There has been an explosion of clinical trials over the past decade both further examining corticosteroid use and ushering in additional treatment considerations, including two newly approved therapies for IgAN. Sodium glucose cotransporter-2 inhibitors are proving to be effective therapy across proteinuric chronic kidney diseases, and IgAN is not likely to be an exception. Further supportive agents are looking highly promising and so are novel agents that specifically focus on the pathophysiology of this disease, including endothelin blockade, complement inhibition and B cell targeted strategies. We suggest a present-day approach to treatment of individuals with IgAN, expose limitations in our knowledge, and discuss new treatments that may arise, hoping they come with evidence about optimal utilization. Change appears to be inevitable for our approach to the treatment of IgA nephropathy. This is truly an exciting and optimistic time.
View details for DOI 10.1053/j.ajkd.2023.08.007
View details for PubMedID 37742867