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Treatment effect of canagliflozin for patients on therapy for heart failure: Pooled analysis of the CANVAS program and CREDENCE trial.

Treatment effect of canagliflozin for patients on therapy for heart failure: Pooled analysis of the CANVAS program and CREDENCE trial. International journal of cardiology Jain, S. S., Yu, J., Arnott, C., Neal, B., Perkovic, V., Neuen, B. L., Jardine, M., Mahaffey, K. W. 2023: 131444

Abstract

Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that has been shown to reduce cardiovascular events in diabetic patients with and without heart failure (HF). Whether the clinical benefits and safety profile of canagliflozin are different in those on a beta blocker and an angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (BB?+?RAASi) is unknown.We pooled participants with HF at baseline from the CANVAS Program and CREDENCE trial and assessed major adverse cardiovascular events and its components; hospitalization for heart failure (HHF); HHF or CV death; all-cause mortality; a renal composite; and a combined renal and CV composite.Of 14,543 participants, 2113 had HF at baseline, and 1280 were on BB?+?RAASi. In those with a history of HF, participants on BB?+?RAASi therapy were more likely to have coronary atherosclerotic disease (82 vs 72%, p?

View details for DOI 10.1016/j.ijcard.2023.131444

View details for PubMedID 37844669