PARAMETRIC IMAGES OF MYOCARDIAL METABOLIC-RATE OF GLUCOSE GENERATED FROM DYNAMIC CARDIAC PET AND 2-[F-18]FLUORO-2-DEOXY-D-GLUCOSE STUDIES JOURNAL OF NUCLEAR MEDICINE Choi, Y., HAWKINS, R. A., Huang, S. C., Gambhir, S. S., Brunken, R. C., Phelps, M. E., Schelbert, H. R. 1991; 32 (4): 733-738

Abstract

We describe a method for generating parametric images of the myocardial metabolic rate of glucose (MMRGlc) with positron emission tomography (PET). The method employs serially acquired images of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake and a Patlak graphical analysis of the image data. The arterial input function is derived from images of the left ventricular blood pool calibrated with 18F-plasma measurements. The approach is computationally fast enough to be used in a clinical environment. The MMRGlc parametric images improve myocardial contrast relative to non-parametric images, especially in studies with poor myocardial uptake of FDG. In addition, MMRGlc parametric images consolidate the large amount of data in a dynamic PET study into a clinically usable image set.

View details for Web of Science ID A1991FG79700031

View details for PubMedID 2013815