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The manatee variational autoencoder model for predicting gene expression alterations caused by transcription factor perturbations.
The manatee variational autoencoder model for predicting gene expression alterations caused by transcription factor perturbations. Scientific reports Yang, Y., Seninge, L., Wang, Z., Oro, A., Stuart, J. M., Ding, H. 2024; 14 (1): 11794Abstract
We present the Manatee variational autoencoder model to predict transcription factor (TF) perturbation-induced transcriptomes. We demonstrate that the Manatee in silico perturbation analysis recapitulates target transcriptomic phenotypes in diverse cellular lineage transitions. We further propose the Manatee in silico screening analysis for prioritizing TF combinations targeting desired transcriptomic phenotypes.
View details for DOI 10.1038/s41598-024-62620-z
View details for PubMedID 38782963
View details for PubMedCentralID PMC11116378