Hemodynamic Influences on abdominal aortic aneurysm disease: Application of biomechanics to aneurysm pathophysiology VASCULAR PHARMACOLOGY Dua, M. M., Dalman, R. L. 2010; 53 (1-2): 11-21


"Atherosclerotic" abdominal aortic aneurysms (AAAs) occur with the greatest frequency in the distal aorta. The unique hemodynamic environment of this area predisposes it to site-specific degenerative changes. In this review, we summarize the differential hemodynamic influences present along the length of the abdominal aorta, and demonstrate how alterations in aortic flow and wall shear stress modify AAA progression in experimental models. Improved understanding of aortic hemodynamic risk profiles provides an opportunity to modify patient activity patterns to minimize the risk of aneurysmal degeneration.

View details for DOI 10.1016/j.vph.2010.03.004

View details for Web of Science ID 000278450300002

View details for PubMedID 20347049

View details for PubMedCentralID PMC2880166