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Difference between kidney function by cystatin C versus creatinine and association with muscle mass and frailty.

Difference between kidney function by cystatin C versus creatinine and association with muscle mass and frailty. Journal of the American Geriatrics Society Yuan, J. H., Rifkin, D. E., Ginsberg, C., Cawthon, P. M., Kado, D. M., Bauer, S. R., Ensrud, K. E., Hoffman, A. R., Potok, O. A. 2024

Abstract

A higher difference in estimated glomerular filtration rate by cystatin C versus creatinine (eGFRDiff?=?eGFRCys - eGFRCreat) is associated with decreased frailty risk. Since eGFRCreat is influenced by muscle more than eGFRCys, muscle mass may explain this association. Previous work could not account for this when considering regional muscle measures by imaging. Deuterated creatine (D3Cr) dilution measures whole body muscle mass (kilograms). We aimed to determine whether eGFRDiff is associated with D3Cr muscle mass and whether muscle mass explains the association between eGFRDiff and frailty.Cross-sectional analysis within the multicenter MrOS Study at Year 14 (visit 4). 490 men of the original cohort of 5994 MrOS participants (aged =65 at enrollment) were included. Exposure was eGFRDiff (= eGFRCys - eGFRCreat), calculated using CKD-EPI equations 2012/2021. Primary outcome was D3Cr muscle mass. Secondary outcome was phenotypic pre-frailty (one or two criteria) and frailty (=three criteria) including the following: weight loss, weakness, slow gait, physical activity, poor energy. The association of eGFRDiff with D3Cr muscle mass was examined by linear regression, that with prefrailty / frailty by multinomial logistic regression.Mean?±?SD age was 84?±?4?years, eGFRCreat 68?±?16, eGFRCys 52?±?16, eGFRDiff -15?±?12?mL/min/1.73?m2 and D3Cr muscle mass 24?±?4?kg. For each SD increment in eGFRDiff, D3Cr muscle mass was 1.4?kg higher on average, p?

View details for DOI 10.1111/jgs.19014

View details for PubMedID 38819605