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Expanding Selection Criteria in Deceased Donor Liver Transplantation for Hepatocellular Carcinoma: Long-term Follow-up of a National Registry and 2 Transplant Centers.

Expanding Selection Criteria in Deceased Donor Liver Transplantation for Hepatocellular Carcinoma: Long-term Follow-up of a National Registry and 2 Transplant Centers. Transplantation Wehrle, C. J., Kusakabe, J., Akabane, M., Maspero, M., Zervos, B., Modaresi Esfeh, J., Whitsett Linganna, M., Imaoka, Y., Khalil, M., Pita, A., Kim, J., Diago-Uso, T., Fujiki, M., Eghtesad, B., Quintini, C., Kwon, C. D., Pinna, A., Aucejo, F., Miller, C., Mazzaferro, V., Schlegel, A., Sasaki, K., Hashimoto, K. 2024

Abstract

This study compares selection criteria for liver transplant (LT) for hepatocellular carcinoma (HCC) for inclusivity and predictive ability to identify the most permissive criteria that maintain patient outcomes.The Scientific Registry of Transplant Recipients (SRTR) database was queried for deceased donor LT's for HCC (2003-2020) with 3-y follow-up; these data were compared with a 2-center experience. Milan, University of California, San Francisco (UCSF), 5-5-500, Up-to-seven (U7), HALT-HCC, and Metroticket 2.0 scores were calculated.Nationally, 26?409 patients were included, and 547 at the 2 institutions. Median SRTR-follow-up was 6.8 y (interquartile range 3.9-10.1). Three criteria allowed the expansion of candidacy versus Milan: UCSF (7.7%, n?=?1898), Metroticket 2.0 (4.2%, n?=?1037), and U7 (3.5%, n?=?828). The absolute difference in 3-y overall survival (OS) between scores was 1.5%. HALT-HCC (area under the curve [AUC]?=?0.559, 0.551-0.567) best predicted 3-y OS although AUC was notably similar between criteria (0.506?

View details for DOI 10.1097/TP.0000000000005097

View details for PubMedID 38831488