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Targeting APRIL in the treatment of glomerular diseases.
Targeting APRIL in the treatment of glomerular diseases. Kidney international Cheung, C. K., Barratt, J., Lafayette, R., Liew, A., Suzuki, Y., Tesar, V., Trimarchi, H., Wong, M. G., Zhang, H., Rizk, D. V. 2024Abstract
A PRoliferation Inducing Ligand (APRIL) is a key member of the tumor necrosis factor (TNF)-superfamily of cytokines, and plays a central role in B cell survival, proliferation and immunoglobulin class switching. Recently, there has been increasing interest in the role of APRIL and the related cytokine B cell activating factor (BAFF) in several glomerular diseases, due to their importance in the above processes. The therapeutic inhibition of APRIL represents a potentially attractive immunomodulatory approach, that may abrogate deleterious host immune responses in autoimmune diseases while leaving other important functions of humoral immunity intact, such as memory B cell function and responses to vaccination, in contrast to B cell depleting strategies. In this review, we describe the physiological roles of APRIL in B cell development and their relevance to glomerular diseases, and outline emerging clinical trial data studying APRIL inhibition, with a focus on IgA nephropathy where the clinical development of APRIL inhibitors is in its most advanced stage.
View details for DOI 10.1016/j.kint.2024.08.012
View details for PubMedID 39182759