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Clinical, mechanistic, and therapeutic landscape of cutaneous fibrosis.

Clinical, mechanistic, and therapeutic landscape of cutaneous fibrosis. Science translational medicine Li, D. J., Berry, C. E., Wan, D. C., Longaker, M. T. 2024; 16 (766): eadn7871

Abstract

When dysregulated, skin fibrosis can lead to a multitude of pathologies. We provide a framework for understanding the wide clinical spectrum, mechanisms, and management of cutaneous fibrosis encompassing a variety of matrix disorders, fibrohistiocytic neoplasms, injury-induced scarring, and autoimmune scleroses. Underlying such entities are common mechanistic pathways that leverage morphogenic signaling, immune activation, and mechanotransduction to modulate fibroblast function. In light of the limited array of available treatments for cutaneous fibrosis, scientific insights have opened new therapeutic and investigative avenues for conditions that still lack effective interventions.

View details for DOI 10.1126/scitranslmed.adn7871

View details for PubMedID 39321265