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Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute rejection in pediatric and adult bowel transplant.
Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute rejection in pediatric and adult bowel transplant. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Levitte, S., Zhang, K. Y., Guevara-Tique, A. A., Ganguly, A., Dulken, B. W., Nilkant, R., Rigmaiden, M., Kumari, R., Khlifi, K., Thakor, A. S., Bonham, C. A. 2023Abstract
Mesenchymal stem cells are under investigation as a novel therapy to treat solid organ transplant rejection. However, significant hurdles have limited their use in humans. Mesenchymal stem cell-derived extracellular vesicles address many of these shortcomings but have not been investigated clinically. Here we report our experience treating two patients with graft rejection and inflammation following bowel transplant using mesenchymal stem cell-derived extracellular vesicles.
View details for DOI 10.1016/j.ajt.2023.10.019
View details for PubMedID 39491097